Survey of the diagnosis and management of antisperm antibodies
| Autor: | A.H. Balen, J A Krapez, Anthony J. Rutherford, Catherine J. Hayden |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Infertility medicine.medical_specialty medicine.medical_treatment Reproductive medicine Semen Insemination Antibodies Intracytoplasmic sperm injection Human fertilization Surveys and Questionnaires medicine Humans Insemination Artificial Autoantibodies Gynecology biology Artificial insemination Rehabilitation Obstetrics and Gynecology medicine.disease Spermatozoa Reproductive Medicine biology.protein Female Antibody |
| Zdroj: | Human Reproduction. 13:3363-3367 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/13.12.3363 |
| Popis: | A questionnaire was sent to all Human Fertilization and Embryology Authority-registered reproductive medicine centres throughout the UK to survey their policy for the diagnosis and management of antisperm antibodies. Forty-eight responses were received from the 74 units that use husbands' spermatozoa for treatments (65%). Most centres use at least one test to detect antibodies, although a minority perform no tests on the basis that their clinical practice would be unaltered if antibodies were present. Positive tests are classed as clinically significant at levels varying from > or = 10% to > or = 50% for direct sperm binding tests (mixed antiglobulin reaction, immunobead test), and ranging from any positive reaction to > or = 1:32 for the microtitre tests (gelatin and tray agglutination tests, microimmobilization test). Strategies for managing affected patients include no intervention, artificial insemination and intrauterine insemination (IUI) using spermatozoa prepared by various techniques, in-vitro fertilization (IVF) with or without increased insemination concentration, and intracytoplasmic sperm injection. Criteria for the latter are diverse, some centres managing all antibody-positive patients this way, while others resort to it only in severe cases or after other treatments have failed. Half of the respondents occasionally or regularly employ steroids, either alone or in conjunction with IUI or IVF. Overall, it appears that much confusion exists as to how best to manage couples presenting with antibody-related infertility. |
| Databáze: | OpenAIRE |
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