Lipoprotein parameters in relation to other risk factors of atherosclerosis in adults and newborns: Tallinn Young Family Study
| Autor: | Matti Jauhiainen, R. Jordania, E. Kurvinen, Jouko Sundvall, Katrin Aasvee |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Arteriosclerosis Clinical Biochemistry Body Mass Index Risk Factors Hyperlipidemia Birth Weight Body Size Young adult Hypertriglyceridemia biology Obstetrics Smoking Age Factors General Medicine Lipoprotein(a) Fetal Blood Cholesterol Cord blood Cohort Regression Analysis Female lipids (amino acids peptides and proteins) Adult Estonia medicine.medical_specialty Adolescent Lipoproteins Hypercholesterolemia Hyperlipidemias Statistics Nonparametric Sex Factors Internal medicine medicine Humans Triglycerides Apolipoproteins B Family Health business.industry Cholesterol HDL Infant Newborn Coronary risk factors nutritional and metabolic diseases Cholesterol LDL medicine.disease Endocrinology Apgar Score biology.protein business Body mass index Lipoprotein |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 64:245-254 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365510410006009 |
| Popis: | A cohort of young families from Tallinn was studied for coronary risk factors. In sera from 239 adults and cord blood from 138 of their newborns, TC, HDL-C, LDL-C, TG, Lp(a) and apo-B levels were determined, and body mass index (BMI) and lifestyle factors were registered. In newborns, characteristics of maturity were assessed by Dubowitz and Apgar scores after birth. The aim of the study was to investigate the risk factors for atherosclerosis in young families and to reveal the main determinants of atherogenic lipoprotein parameters in adults and newborns. Using the criteria of the International Lipid Information Bureau, it was found that 24.4% of the men and 9.8% of the women were hypercholesterolemic, 31.5% of the men and 9.6% of the women had low HDL-C, TG levels were elevated accordingly in 5.3% and 1.2% of subjects. The independent determinants of TG level in males were BMI and age, and for LDL-C and apo-B levels--BMI, age and nationality. Female neonates had higher TC, HDL-C and apo-B levels than male neonates, the differences seeming to be associated with the different physiological requirements of male and female fetuses. Newborns' HDL-C levels were correlated positively with their TCs (r=0.72; p0.001), LDL-C (r=0.47; p0.001) and apo B (r=0.23; p0.05). A negative linear correlation was found between neonates' TC levels and the Dubowitz maturity score (r=-0.22; p=0.038). Serum Lp(a) levels did not differ significantly between males and females, either in adults or in newborns. The independent determinants of neonates' serum Lp(a) concentrations were parents' serum levels of Lp(a) and nationality. |
| Databáze: | OpenAIRE |
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