BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latinas: The UPTAKE study
Autor: | Patricia Vázquez Rodríguez, Ilana Schlam, Xue Geng, Julie Dutil, Beth N. Peshkin, Kristi D. Graves, Jaeil Ahn, Zeina Nahleh, Charité Ricker, Filipa Lynce, Claudine Isaacs, Neelima Denduluri, Sue Friedman, Claudia Campos |
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Rok vydání: | 2020 |
Předmět: |
Oncology
medicine.medical_specialty Genetic counseling Ovariectomy Ethnic group Salpingo-oophorectomy Breast Neoplasms Logistic regression Article 03 medical and health sciences 0302 clinical medicine Germline mutation Breast cancer Internal medicine medicine Humans Genetic Predisposition to Disease Genetics (clinical) Genetic testing Uptake study BRCA2 Protein Ovarian Neoplasms 0303 health sciences medicine.diagnostic_test business.industry BRCA1 Protein 030305 genetics & heredity Hispanic or Latino medicine.disease Bilateral salpingo-oophorectomy 030220 oncology & carcinogenesis Mutation Female business |
Zdroj: | J Genet Couns |
ISSN: | 1573-3599 |
Popis: | Bilateral salpingo-oophorectomy (BSO) is a risk management approach with strong evidence of mortality reduction for women with germline mutations in the tumor suppressor genes BRCA1 and BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds who carry BRCA1/2 mutations. The objective of the UPTAKE study was to explore rates and predictors of risk-reducing BSO among Latinas affected and unaffected with breast cancer who had a deleterious BRCA1/2 mutation. We recruited 100 Latina women with deleterious BRCA1/2 mutations from community hospitals, academic health systems, community, and advocacy organizations. Women completed interviews in Spanish or English. We obtained copies of genetic test reports for participants who provided signed medical release. After performing threefold cross-validation LASSO for variable selection, we used multiple logistic regression to identify demographic and clinical predictors of BSO. Among 100 participants, 68 had undergone BSO at the time of interview. Of these 68, 35 were US-born (61% of all US-born participants) and 33 were not (77% of the non-US-born participants). Among Latinas with BRCA1/2 mutations, older age (p = 0.004), personal history of breast cancer (p = 0.003), higher income (p = 0.002), and not having a full-time job (p = 0.027) were identified as variables significantly associated with uptake of BSO. Results suggest a high rate of uptake of risk-reducing BSO among a sample of Latinas with BRCA1/2 mutations living in the US. We document factors associated with BSO uptake in a diverse sample of women. Relevant to genetic counseling, our findings identify possible targets for supporting Latinas' decision-making about BSO following receipt of a positive BRCA1/2 test. |
Databáze: | OpenAIRE |
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