Differentiating between smokers and nonsmokers using serum cotinine
| Autor: | Erin L. Tompkins, Sheryl A Bedno, Thomas A Beltran |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male National Health and Nutrition Examination Survey Clinical Biochemistry 030204 cardiovascular system & hematology Nicotine 03 medical and health sciences chemistry.chemical_compound Serum cotinine 0302 clinical medicine Drug Discovery Medicine Humans 030212 general & internal medicine Cotinine Smokers Receiver operating characteristic business.industry Biochemistry (medical) Smoking Non-Smokers Middle Aged Cross-Sectional Studies chemistry Female business Cut-point Biomarkers medicine.drug Demography |
| Zdroj: | Biomarkers in medicine. 13(12) |
| ISSN: | 1752-0371 |
| Popis: | Aim: Our goal is to evaluate implications of cotinine cut points in subgroups of smokers and nonsmokers. Materials & methods: Data were assessed from 13,357 adult participants and collected over a period of 6 years by the National Health and Nutrition Examination Survey (2009–2014). Receiver operating characteristic curve analysis was used to identify optimal cut points. Rao–Scott χ2 tests measured associations between group characteristics. Results: The optimal serum cotinine cut point adult cigarette smokers was 3.63 ng/ml (sensitivity of 96.7%; specificity of 93.0%). This cut point differed by gender as well as race/ethnicity. Conclusion: There are notable differences in subgroup cut points compared with previous research. Use of gender or race/ethnicity specific cut points is more appropriate when feasible and may help clinician recommendations. |
| Databáze: | OpenAIRE |
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