The immunoregulatory effects of co-infection with Fasciola hepatica : From bovine tuberculosis to Johne's disease
| Autor: | Amalia Naranjo Lucena, Grace Mulcahy, Annetta Zintl, Laura Garza Cuartero |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fascioliasis 040301 veterinary sciences Paratuberculosis Cattle Diseases 0403 veterinary science Immunomodulation 03 medical and health sciences Hepatica Immunity parasitic diseases medicine Fasciola hepatica Animals Fasciolosis Mycobacterium bovis General Veterinary biology Coinfection 04 agricultural and veterinary sciences Liver fluke medicine.disease biology.organism_classification Virology 3. Good health Mycobacterium avium subsp. paratuberculosis 030104 developmental biology Cattle diseases Immunology Animal Science and Zoology Cattle Johne's disease Tuberculosis Bovine |
| Zdroj: | The Veterinary Journal |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2017.02.007 |
| Popis: | Fasciola hepatica (liver fluke) is a parasite prevalent in much of the world that causes the economically-important disease of fasciolosis in livestock. The threat that this disease poses extends beyond its direct effects due to the parasite's immunomodulatory effects. Research at this laboratory is focusing on whether this immunoregulation can, in animals infected with liver fluke, exert a bystander effect on concurrent infections in the host. It has already been established that F. hepatica infection reduces cell mediated immune responses to Mycobacterium bovis in cattle, and that the interaction between the two pathogens can be detected on an epidemiological scale. This review explores the immunological consequences of co-infection between F. hepatica and other bacterial infections. Arguments are presented suggesting that immunity of cattle to Mycobacterium avium subsp. paratuberculosis is also likely to be affected. European Commission Horizon 2020 |
| Databáze: | OpenAIRE |
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