Concomitant use of corticosteroid and antimicrobials for liver abscesses in patients with chronic granulomatous disease
| Autor: | Moo Sook Lee, Kyung Sue Shin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
congenital hereditary and neonatal diseases and abnormalities medicine.drug_class Inflammation Case Report Pediatrics Gastroenterology 03 medical and health sciences 0302 clinical medicine Chronic granulomatous disease Refractory immune system diseases Internal medicine hemic and lymphatic diseases medicine Corticosteroid 030212 general & internal medicine Genitourinary system business.industry lcsh:RJ1-570 lcsh:Pediatrics Antimicrobial medicine.disease Liver abscess 030220 oncology & carcinogenesis Concomitant Pediatrics Perinatology and Child Health Immunology medicine.symptom business |
| Zdroj: | Korean Journal of Pediatrics, Vol 59, Iss 4, Pp 196-201 (2016) Korean Journal of Pediatrics |
| ISSN: | 2092-7258 1738-1061 |
| Popis: | Chronic granulomatous disease (CGD) is a rare inherited disorder caused by defective nicotinamide adenine dinucleotide phosphate oxidase enzyme and characterized by recurrent bacterial and fungal infections. Although liver abscess is a common manifestation of CGD, its management in CGD patients is not well-defined. In addition, the generalized guidelines for treating liver abscesses do not necessarily apply to CGD patients. Corticosteroids are commonly used to control granulomatous complications, such as inflammatory gastrointestinal and genitourinary lesions, in patients with CGD, Corticosteroids have also been used in combination with antimicrobials to treat refractory infections in patients with CGD. Because corticosteroids are capable of suppressing symptomatic inflammation, all potential infections must be adequately controlled prior to corticosteroid initiation. We report 3 typical CGD cases with liver abscesses refractory to conventional treatments that were successfully treated with the concomitant use of corticosteroid and antimicrobials. It remains unclear whether corticosteroid therapy is required for liver abscesses in CGD refractory to conventional treatments. However, based on our observations, use of corticosteroids in combination with optimal antimicrobials should be considered for refractory liver abscesses in CGD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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