Cardiovascular and Renal Calcification and Bone : A comparison of the effect of Dietary Fatty Acids
| Autor: | John McLaren Howard, Michael Y. Henein, Rachel Nicoll |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Kardiologi Osteoporosis lcsh:R Fatty acid lcsh:Medicine Inflammation Biology medicine.disease medicine.disease_cause Fish oil Ectopic calcification Arterial calcification Endocrinology chemistry lcsh:RC666-701 Internal medicine medicine Cardiac and Cardiovascular Systems medicine.symptom Oxidative stress Calcification |
| Zdroj: | International Cardiovascular Forum Journal, Vol 1, Iss 3, Pp 127-131 (2014) |
| Popis: | Cardiovascular (CV) and renal calcification is regularly found with osteoporosis and both are conditions of chronicinflammation and oxidative stress. Intake of dietary fatty acids is known to impact on the incidence of CV disease and boneloss but few studies have specifically looked at their impact on CV or renal calcification. This review found that although avery high total fat intake is likely to prove detrimental to both tissues and bone, particularly with low calcium intake, humanstudies often show mixed results, possibly because fatty acid intake shows a U-shaped dose/response curve, contrary to theexpected linear relationship. Nevertheless, intake of fish and fish oil are generally found to protect against ectopic calcificationand bone loss, with a low omega 6 to omega 3 ratio (preferably believed to be optimal. In arteries, the relationship between fish oil intake and other markers of sub-clinical atherosclerosis,such as intima-medial thickness, may be stronger than their relationship with arterial calcification. Any association with arterialcalcification often lost significance after adjustment for CV risk factors, suggesting that fish oil may act principally by loweringrisk factors and calling into question whether CV calcification is a condition of dyslipidaemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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