Assessing brain iron and volume of subcortical nuclei in idiopathic rapid eye movement sleep behavior disorder
| Autor: | Xianchang Zhang, Shuang Xia, Yaqin Huang, Tong Zhang, Jingyi Ye, Jinxia Zhu, Chao Chai, Zhi-Yun Wang, Xuan Zhang, Wei Wu, Kiarash Ghassaban, E. Mark Haacke, Rong Xue |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Iron Caudate nucleus Rapid eye movement sleep Substantia nigra REM Sleep Behavior Disorder Timed Up and Go test REM sleep behavior disorder 030218 nuclear medicine & medical imaging 03 medical and health sciences Behavior disorder 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans Postural Balance business.industry Brain Quantitative susceptibility mapping medicine.disease Time and Motion Studies Susceptibility weighted imaging Cardiology Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Sleep. 44 |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/zsab131 |
| Popis: | Study Objectives The relationship of iron with cognitive and motor impairment in idiopathic rapid eye movement sleep behavior disorder (iRBD) remains unknown. Methods Twenty-nine (29) patients and 28 healthy controls (HCs) underwent susceptibility weighted imaging and susceptibility mapping. These images were used to evaluate the nigrosome-1 (N1) sign in the substantia nigra (SN), global and regional high-iron (RII) content, and volume of subcortical nuclei. Results The number of iRBD patients with N1 loss (12) was significantly higher than HCs (2) (p = 0.005). Compared with HCs, the iRBD patients had reduced volume of the right caudate nucleus (RCN) (p < 0.05, false discovery rate [FDR] correction) but no significant changes in global and RII iron of the subcortical nuclei (all p > 0.05, FDR correction). Multiple regression analysis revealed that: for cognitive function, the RII iron of the RCN was significantly correlated with visuospatial function and the global iron of the right dentate nucleus (RDN) was correlated with memory function; for motor function, the RII iron of the left DN (LDN) and global iron of the left CN correlated with the Alternate-Tap test (left, average), the global iron of the LDN correlated with the Alternate-Tap test (right), and the global iron of the left GP correlated with the 3-m Timed Up and Go test (all p < 0.05, FDR correction). Conclusions Our exploratory analysis found that iRBD patients had a higher incidence of N1 loss and reduced RCN volume after FDR correction. Cognitive and motor impairment were associated with iron deposition in several cerebral nuclei after FDR correction. |
| Databáze: | OpenAIRE |
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