Antidiabetic Actions of an Estrogen Receptor β Selective Agonist
| Autor: | Ana B. Ropero, S Albert Salehi, Sergi Soriano, Marta García-Arévalo, Angel Nadal, Paloma Alonso-Magdalena, Sarheed Jabar Muhammed, Jan-Åke Gustafsson, Ivan Quesada |
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| Přispěvatelé: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Fisiología de Membranas |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Niacinamide Agonist medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Estrogen receptor Enzyme-Linked Immunosorbent Assay Estrogen receptor β In Vitro Techniques Biology Fisiología Streptozocin Diabetes Mellitus Experimental Islets of Langerhans Mice Insuline Phenols In vivo Insulin-Secreting Cells Diabetes mellitus Internal medicine Internal Medicine medicine Animals Estrogen Receptor beta Humans Hypoglycemic Agents Insulin Endocrine pancreas Oxazoles Cells Cultured Estrogen receptor beta Original Research Diabetes medicine.disease Insulin oscillation Mice Inbred C57BL medicine.anatomical_structure Endocrinology Glucose Islet Studies Pancreas |
| Zdroj: | RUA. Repositorio Institucional de la Universidad de Alicante Universidad de Alicante (UA) Diabetes |
| Popis: | The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administration of WAY200070 leads to an increase in plasma insulin levels with a concomitant improved response to a glucose load. Two-week treatment administration increased glucose-induced insulin release and pancreatic β-cell mass and improved glucose and insulin sensitivity. In addition, streptozotocin-nicotinamide–induced diabetic mice treated with WAY200070 exhibited a significant improvement in plasma insulin levels and glucose tolerance as well as a regeneration of pancreatic β-cell mass. Studies performed in db/db mice demonstrated that this compound restored first-phase insulin secretion and enhanced pancreatic β-cell mass. We conclude that ERβ agonists should be considered as new targets for the treatment of diabetes. This work was supported by Generalitat Valenciana grant PROMETEO/2011/080, Ministerio de Economia y Competitividad BFU2011-28358, and Ministerio de Economía y Competitividad BFU2010-21773 and BFU2008-1942; the Swedish Cancer Fund; the Emerging Technology Fund of Texas; and the Robert A. Welch Foundation (E-0004). |
| Databáze: | OpenAIRE |
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