Tanning salon exposure and molecular alterations
Autor: | Caroline Chadwick b, Warwick L. Morison, Christopher S. Potten, S. Elizabeth Whitmore |
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Rok vydání: | 2001 |
Předmět: |
Adult
Keratinocytes Male Pathology medicine.medical_specialty Adolescent Ultraviolet Rays DNA damage Pyrimidine dimer Dermatology Reference Values Biopsy medicine Humans skin and connective tissue diseases integumentary system Human studies medicine.diagnostic_test business.industry Commerce Extremely Helpful medicine.disease Immunohistochemistry United States Peripheral blood Pyrimidine Dimers Immunology Female Sun exposure Tumor Suppressor Protein p53 Skin cancer business DNA Damage |
Zdroj: | Journal of the American Academy of Dermatology. 44:775-780 |
ISSN: | 0190-9622 |
Popis: | Background: Human studies of the short-term cellular effects of tanning salon exposures are lacking. Findings of such studies may prove extremely helpful in educating consumers considering or currently attending tanning salons. Objective: Our purpose was to determine whether tanning salon exposure causes DNA alterations and p53 protein expression in epidermal keratinocytes and/or circulating peripheral lymphocytes. Methods: Eleven subjects received 10 full-body tanning salon exposures over a 2-week period. UV-induced DNA cyclobutane pyrimidine dimers and p53 protein expression were examined, comparing pretreatment peripheral blood lymphocytes and epidermal biopsy specimens with analogous specimens obtained after the 10 tanning salon exposures. Results: Cyclobutane pyrimidine dimers in DNA and p53 protein expression were detected in epidermal keratinocytes, but were absent in lymphocytes. Conclusion: Similar to outdoor sun exposure, short-term recreational tanning salon exposure causes molecular alterations believed essential in the development of skin cancer. (J Am Acad Dermatol 2001;44:775-80.) |
Databáze: | OpenAIRE |
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