'Clickable' Hydrosoluble PEGylated Cryptophane as a Universal Platform for129Xe Magnetic Resonance Imaging Biosensors

Autor:	Ténin Traoré, Céline Puente, Patrick Berthault, Sébastien Garcia-Argote, François Leteurtre, Céline Boutin, Edmond Gravel, Nawal Tassali, Bernard Rousseau, Estelle Léonce, Yves Boulard, Naoko Kotera, Léa Delacour
Rok vydání:	2013
Předmět:	Magnetic Resonance Spectroscopy Xenon medicine.diagnostic_test Chemistry Organic Chemistry Water Magnetic resonance imaging Nanotechnology Biosensing Techniques General Chemistry Nuclear magnetic resonance spectroscopy Catalysis Cryptophane medicine Click chemistry Click Chemistry Polycyclic Compounds Clickable Biosensor
Zdroj:	Chemistry - A European Journal. 19:6089-6093
ISSN:	0947-6539
DOI:	10.1002/chem.201204218
Popis:	We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of (129)Xe magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized (129)Xe MRI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658bc34f4eeec6f9aa9ff401779ba942 https://doi.org/10.1002/chem.201204218 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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