Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia
| Autor: | Dragan Ljutić, Ana Simičić Majce, Natalija Filipović, Adela Arapović, Danica Ljubanović-Galešić, Sandra Prgomet, Marijan Saraga, Anja Belavić, Mirna Saraga-Babić, Katarina Vukojević, Dijana Borić Škaro, Merica Glavina Durdov |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Adolescent Croatia Epidemiology Biopsy Nephrotic syndrome Kidney urologic and male genital diseases lcsh:RC870-923 Gastroenterology Nephritic syndrome Focal segmental glomerulosclerosis Internal medicine medicine Humans Minimal change disease Registries Child Retrospective Studies Nephritis medicine.diagnostic_test business.industry Glomerulonephritis Glomerulonephritis IGA medicine.disease lcsh:Diseases of the genitourinary system. Urology Microscopy Electron Child Preschool renal biopsy nephrotic syndrome Female Kidney Diseases Renal biopsy business Tubulointerstitial Disease Glomerular Filtration Rate Research Article |
| Zdroj: | BMC Nephrology, Vol 21, Iss 1, Pp 1-12 (2020) BMC Nephrology |
| ISSN: | 1471-2369 |
| Popis: | Background Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia. Methods Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Kidney allograft biopsy, and re-biopsy were excluded. The biopsy sections were examined under light microscopy, immunofluorescence and electron microscopy. The data was reviewed to determine the pathohistological spectrum and clinicopathologic correlations. We retrospectively analyzed kidney biopsy data from 2008 to 2017 and compared them to that between 1995 and 2005. Results The mean age of patients was 9.84 ± 5.4 years. Male:female ratio was 1.2:1. The main indications for biopsy were pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%). The most common pathohistological findings were IgA nephropathy (IgAN, 24.1%), minimal change disease (MCD, 16.7%), Henoch-Schönlein purpura glomerulonephritis (HSPN, 14.8%), Alport syndrome and focal segmental glomerulosclerosis (AS and FSGS, 11.1% each), tubulointerstitial nephritis and membranous glomerulopathy (TIN and MGN, 3.7% each), while other cases were diagnosed rarely. Conclusions Changes in epidemiology of renal diseases in children between the analyzed periods showed an increasing trend of IgAN, MCD, HSPN, AS and FSGS, while mesangioproliferative glomerulonephritis (MesPGN) and endoproliferative glomerulonephritis (EDGN) showed a decreasing trend that can be explained with the new pathohistological classification. |
| Databáze: | OpenAIRE |
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