Kidney disease in RA patients: prevalence and implication on RA-related drugs management: the MATRIX study
| Autor: | Serge Rozenberg, Svetlana Karie, Vincent Launay-Vacher, Gilbert Deray, Pierre Bourgeois, C. U. Mai Ba, Nicolas Janus, F. Gandjbakhch |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinalysis Urology Renal function Comorbidity Kidney Function Tests urologic and male genital diseases Risk Assessment Drug Administration Schedule Nephrotoxicity Arthritis Rheumatoid chemistry.chemical_compound Age Distribution Rheumatology Prevalence medicine Humans Pharmacology (medical) Prospective Studies Sex Distribution Prospective cohort study Aged Creatinine Kidney Proteinuria Dose-Response Relationship Drug medicine.diagnostic_test business.industry Middle Aged medicine.disease Surgery Methotrexate medicine.anatomical_structure chemistry Antirheumatic Agents Female Kidney Diseases medicine.symptom business Follow-Up Studies Glomerular Filtration Rate Kidney disease |
| Zdroj: | Rheumatology. 47:350-354 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/kem370 |
| Popis: | Objectives. The prevalence of kidney disease (KD) indicators together with the profile of RA drugs prescribed in RA patients was investigated in the MATRIX study (MeThotreXate And Renal Insufficiency). Methods. Renal function (RF) was assessed using Cockcroft–Gault (CG) and abbreviated Modification of Diet in Renal Disease (aMDRD) study formulae. Results. Serum creatinine (SCr) was normal in 81.4% of the 129 patients included. According to the National Kidney Foundation (NKF) classification, the distribution by stage of KD was, using the aMDRD and CG formulae, as follows: stage 1: 11.3% and 11.4%; stage 2: 20.0% and 20.3%; stage 3: 15.0% and 24.1%; stage 4: 0% and 1.3%; stage 5: 0%. Proteinuria, haematuria and leucocyturia were observed in 16%, 17% and 20% of the patients, respectively. Using the aMDRD and CG formulae, 36% and 38% of the prescriptions made in patients with glomerular filtration rate (GFR) |
| Databáze: | OpenAIRE |
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