Lens regeneration using endogenous stem cells with gain of visual function
| Autor: | William Shi, Robert A.J. Signer, Yujuan Wang, Christopher W.D. Heichel, Shan Huang, Michal Krawczyk, Gen Li, Daniel Chen, Austin Qiu, Jiangna Chen, Christopher Chung, Danni Lin, Rui Hou, Lixia Luo, Yizhi Liu, Cindy Wen, Zheng Zhong, Huimin Cai, Yanxin Xu, Jin Zhu, Guiqun Cao, Frances Wu, Ying Zhang, Shuyi Chen, Richard L. Maas, Zhenzhen Liu, Jiayi Hou, Shaochen Chen, Sheng Zhong, Liangfang Zhang, Kang Zhang, Fu Shang, Haotian Lin, Sherrina Patel, Xialin Liu, Baoxin Chen, Sean J. Morrison, Dorota Skowronska-Krawczyk, Maryam Jafari, Jie Zhu, Xuri Li, David B. Granet, Hong Ouyang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
China PAX6 Transcription Factor genetic structures Endogeny Cataract Extraction Biology Eye Regenerative medicine Cataract Article law.invention 03 medical and health sciences Cataracts law Proto-Oncogene Proteins Lens Crystalline medicine Animals Homeostasis Paired Box Transcription Factors Humans Regeneration Progenitor cell Eye Proteins Vision Ocular Homeodomain Proteins Polycomb Repressive Complex 1 Multidisciplinary Stem Cells Regeneration (biology) fungi Epithelial Cells Recovery of Function Anatomy medicine.disease eye diseases Cell biology Repressor Proteins Lens (optics) 030104 developmental biology Macaca PAX6 sense organs Stem cell |
| Popis: | The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently, the only treatment for cataracts, the leading cause of blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular lens. However, this procedure poses notable risks of complications. Here we isolate lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal. We design a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts. Our method differs conceptually from current practice, as it preserves endogenous LECs and their natural environment maximally, and regenerates lenses with visual function. Our approach demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells. |
| Databáze: | OpenAIRE |
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