Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing

Autor:	Mariona Parera, Maria Casadellà, Daniel R. Kuritzkes, Henry Sunpath, Marc Noguera-Julian, Michelle Gordon, Vincent C. Marconi, Cristina Simarro Rodríguez, Roger Paredes
Rok vydání:	2016
Předmět:	0301 basic medicine medicine.medical_specialty Genotype Genotyping Techniques Anti-HIV Agents Immunology HIV Infections Drug resistance Microbial Sensitivity Tests Deep sequencing Article 03 medical and health sciences symbols.namesake South Africa 0302 clinical medicine Internal medicine Antiretroviral Therapy Highly Active Epidemiology Drug Resistance Viral medicine Immunology and Allergy Humans 030212 general & internal medicine Treatment Failure Tenofovir Genotyping Sanger sequencing business.industry virus diseases HIV High-Throughput Nucleotide Sequencing 030112 virology Virology Infectious Diseases Cohort symbols business Cohort study
Zdroj:	AIDS (London, England). 30(7)
ISSN:	1473-5571
Popis:	In a South African cohort of participants living with HIV developing virological failure on first-line tenofovir disoproxyl fumarate (TDF)-based regimens, at least 70% of participants demonstrated TDF resistance according to combined Sanger and MiSeq genotyping. Sanger sequencing missed the K65R mutation in 30% of samples. Unless HIV genotyping is available to closely monitor epidemiological HIV resistance to TDF, its efficacy as second-line therapy will be greatly compromised.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658b240e21b2d6451a72da5a50534121 https://pubmed.ncbi.nlm.nih.gov/26807968 Zobrazit plný text záznamu