Renin-Expressing Cells Require β1-Integrin for Survival and for Development and Maintenance of the Renal Vasculature
| Autor: | Rajwinderjit Kaur, Maria Luisa S. Sequeira-Lopez, Brian C. Belyea, Hirofumi Watanabe, Tahagod Mohamed, R. Ariel Gomez, Patrick D. Walker |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell Survival Integrin Apoptosis 030204 cardiovascular system & hematology Biology urologic and male genital diseases Article Mice 03 medical and health sciences Renal Artery 0302 clinical medicine In vivo Renin Renin–angiotensin system Internal Medicine medicine Animals Homeostasis Mice Knockout Kidney urogenital system Cell adhesion molecule Integrin beta1 Juxtaglomerular cell Juxtaglomerular Apparatus Cell biology 030104 developmental biology medicine.anatomical_structure biology.protein Kidney Diseases |
| Zdroj: | Hypertension |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Juxtaglomerular cells are crucial for blood pressure and fluid-electrolyte homeostasis. The factors that maintain the life of renin cells are unknown. In vivo, renin cells receive constant cell-to-cell, mechanical, and neurohumoral stimulation that maintain their identity and function. Whether the presence of this niche is crucial for the vitality of the juxtaglomerular cells is unknown. Integrins are the largest family of cell adhesion molecules that mediate cell-to-cell and cell-to-matrix interactions. Of those, β1-integrin is the most abundant in juxtaglomerular cells. However, its role in renin cell identity and function has not been ascertained. To test the hypothesis that cell-matrix interactions are fundamental not only to maintain the identity and function of juxtaglomerular cells but also to keep them alive, we deleted β1-integrin in vivo in cells of the renin lineage. In mutant mice, renin cells died by apoptosis, resulting in decreased circulating renin, hypotension, severe renal-vascular abnormalities, and renal failure. Results indicate that cell-to-cell and cell-to-matrix interactions via β1-integrin is essential for juxtaglomerular cells survival, suggesting that the juxtaglomerular niche is crucial not only for the tight regulation of renin release but also for juxtaglomerular cell survival—a sine qua non condition to maintain homeostasis. |
| Databáze: | OpenAIRE |
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