Vertical Organic Electrochemical Transistors and Electronics for Low Amplitude Micro-Organ Signals
| Autor: | Myriam Abarkan, Antoine Pirog, Donnie Mafilaza, Gaurav Pathak, Gilles N'Kaoua, Emilie Puginier, Rodney O'Connor, Matthieu Raoux, Mary J. Donahue, Sylvie Renaud, Jochen Lang |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Other Chemical Engineering
biosensor cardiomyocytes diabetes electrophysiology insulin organic electrochemical transistors pancreatic islets General Chemical Engineering General Engineering General Physics and Astronomy Medicine (miscellaneous) Action Potentials General Materials Science Electronics Biochemistry Genetics and Molecular Biology (miscellaneous) Membrane Potentials Annan kemiteknik |
| Popis: | Electrical signals are fundamental to key biological events such as brain activity, heartbeat, or vital hormone secretion. Their capture and analysis provide insight into cell or organ physiology and a number of bioelectronic medical devices aim to improve signal acquisition. Organic electrochemical transistors (OECT) have proven their capacity to capture neuronal and cardiac signals with high fidelity and amplification. Vertical PEDOT:PSS-based OECTs (vOECTs) further enhance signal amplification and device density but have not been characterized in biological applications. An electronic board with individually tuneable transistor biases overcomes fabrication induced heterogeneity in device metrics and allows quantitative biological experiments. Careful exploration of vOECT electric parameters defines voltage biases compatible with reliable transistor function in biological experiments and provides useful maximal transconductance values without influencing cellular signal generation or propagation. This permits successful application in monitoring micro-organs of prime importance in diabetes, the endocrine pancreatic islets, which are known for their far smaller signal amplitudes as compared to neurons or heart cells. Moreover, vOECTs capture their single-cell action potentials and multicellular slow potentials reflecting micro-organ organizations as well as their modulation by the physiological stimulator glucose. This opens the possibility to use OECTs in new biomedical fields well beyond their classical applications. Funding Agencies|ANR MULTISPOTFrench National Research Agency (ANR) [ANR-17-CE09-0015]; ANR DIABLOFrench National Research Agency (ANR) [ANR-18-CE17-0005]; French government "Initiative dexcellence" [AMADEUS-0042]; French Ministry of Education |
| Databáze: | OpenAIRE |
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