The Chicken A and E Blood Systems Arise from Genetic Variation in and around the Regulators of Complement Activation Region

Autor:	Janet E. Fulton, Wiola Drobik-Czwarno, Anna Wolc, Amy M. McCarron, Ashlee R. Lund, Carl J. Schmidt, Robert L. Taylor
Rok vydání:	2022
Předmět:	Isoantigens Immunology Animals Genetic Variation Membrane Proteins Immunology and Allergy Complement C4 Chickens Complement Activation Polymorphism Single Nucleotide Genome-Wide Association Study Immunoglobulin A Immunoglobulin Fc Fragments
Zdroj:	The Journal of Immunology. 209:1128-1137
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.2101010
Popis:	The tightly linked A and E blood alloantigen systems are 2 of 13 blood systems identified in chickens. Reported herein are studies showing that the genes encoding A and E alloantigens map within or near to the chicken regulator of complement activation (RCA) gene cluster, a region syntenic with the human RCA. Genome-wide association studies, sequence analysis, and sequence-derived single-nucleotide polymorphism information for known A and/or E system alleles show that the most likely candidate gene for the A blood system is C4BPM gene (complement component 4 binding protein, membrane). Cosegregation of single-nucleotide polymorphism–defined C4BPM haplotypes and blood system A alleles defined by alloantisera provide a link between chicken blood system A and C4BPM. The best match for the E blood system is the avian equivalent of FCAMR (Fc fragment of IgA and IgM receptor). C4BPM is located within the chicken RCA on chicken microchromosome 26 and is separated from FCAMR by 89 kbp. The genetic variation observed at C4BPM and FCAMR could affect the chicken complement system and differentially guide immune responses to infectious diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65899b8e454a7cb735846fa5923d3d70 https://doi.org/10.4049/jimmunol.2101010 Zobrazit plný text záznamu