Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities
| Autor: | Jianguo Shen, Xinbing Sui, Chenyang Ye, Yunlu Jia, Cong Chen, Yongxia Chen, Hanchu Xiong, Linbo Wang, Jichun Zhou, Ji Yue Wang, Wenhe Zhao, Benjamin J. Seifer |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Lin28 medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Review Radiation Tolerance Metastasis Immunomodulation 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Surgical oncology Internal medicine medicine metastasis Animals Humans Neoplasm Metastasis Therapeutic strategy Cell Proliferation Cancer prevention drug resistance business.industry Cancer RNA-Binding Proteins Epistasis Genetic medicine.disease Radiation therapy Let-7 Gene Expression Regulation Neoplastic 030104 developmental biology Cell Transformation Neoplastic Drug Resistance Neoplasm 030220 oncology & carcinogenesis Christian ministry Female business Energy Metabolism Signal Transduction |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Hanchu Xiong 1,2,* , Wenhe Zhao 1,2,* , Ji Wang 1,2,* , Benjamin J. Seifer 3 , Chenyang Ye 4 , Yongxia Chen 1,2 , Yunlu Jia 1,2 , Cong Chen 1,2 , Jianguo Shen 1,2 , Linbo Wang 1,2 , Xinbing Sui 2,5 and Jichun Zhou 1,2 1 Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China 2 Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, Zhejiang, China 3 USF Health Morsani College of Medicine, Tampa, FL, USA 4 Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education), Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China 5 Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China * These authors have contributed equally to this work Correspondence to: Linbo Wang, email: // Xinbing Sui, email: // Jichun Zhou, email: // Keywords : Lin28; Let-7; breast cancer; metastasis; drug resistance Received : November 09, 2016 Accepted : January 11, 2017 Published : January 29, 2017 Abstract The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer. |
| Databáze: | OpenAIRE |
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