Viscocapillary Instability in Cellular Spheroids
| Autor: | Thomas Risler, Matthieu Martin |
|---|---|
| Přispěvatelé: | Laboratoire Physico-Chimie Curie [Institut Curie] (PCC), Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
dormancy
Viscous shear General Physics and Astronomy FOS: Physical sciences Model parameters spheroids Condensed Matter - Soft Condensed Matter 01 natural sciences Instability 010305 fluids & plasmas 0103 physical sciences cancer Physics - Biological Physics 010306 general physics Tissues and Organs (q-bio.TO) Physics [PHYS]Physics [physics] Spheroid Quantitative Biology - Tissues and Organs Adhesion Physics - Medical Physics viscocapillary instability Biological Physics (physics.bio-ph) FOS: Biological sciences Biophysics Multicellular spheroid Soft Condensed Matter (cond-mat.soft) Circular symmetry Medical Physics (physics.med-ph) Concentration gradient |
| Zdroj: | New Journal of Physics New Journal of Physics, Institute of Physics: Open Access Journals, 2021, 23 (3), pp.033032. ⟨10.1088/1367-2630/abe9d6⟩ |
| ISSN: | 1367-2630 |
| DOI: | 10.48550/arxiv.2102.12340 |
| Popis: | We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular spheroids. In the condition where the cells constituting the spheroid get their necessary metabolites from the immediate, outer microenvironment, a permanent cell flow exists within the spheroid from its outer rim where cells divide toward its core where they die. A perturbation of the spherical symmetry induces viscous shear stresses within the tissue that can destabilise the aggregate. The proposed instability is viscocapillary in nature and does not rely on external heterogeneities, such as a pre-existing pattern of blood vessels or the presence of a substrate on which the cells can exert pulling forces. It arises for sufficiently large cell-cell adhesion strengths, cell-renewal rates, and metabolite supplies, as described by our model parameters. Since multicellular spheroids in culture are good model systems of small, avascular tumours, mimicking the metabolite concentration gradients found in vivo, we can speculate that our description applies to microtumour instabilities in cancer progression. Comment: 22 pages, 5 figures. This is the manuscript version of an article accepted for publication in New Journal of Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|