Methylcobalamin prevents mutant superoxide dismutase-1-induced motor neuron death in vitro
| Autor: | Tetsuhiro Niidome, Shunsuke Ito, Yukina Izumi, Yuichi Ono |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Combination therapy Mice Transgenic Pharmacology Superoxide dismutase Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In Situ Nick-End Labeling medicine Animals Vitamin B12 Amyotrophic lateral sclerosis Cells Cultured Cerebral Cortex Motor Neurons Riluzole Cell Death biology Superoxide Dismutase Superoxide business.industry General Neuroscience Motor neuron Embryo Mammalian medicine.disease Vitamin B 12 Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure chemistry Vitamin B Complex Methylcobalamin biology.protein business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | NeuroReport. 28:101-107 |
| ISSN: | 0959-4965 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is an incurable progressive neurodegenerative disorder that causes motor dysfunction. Treatments and drugs that slow progression of ALS have garnered great interest. In the present study, we show that the vitamin B12 analog methylcobalamin (MBL) effectively and dose dependently prevented embryonic stem cell-derived motor neuron death induced by cocultivation with astrocytes expressing mutant human superoxide dismutase-1 (G93A). Moreover, cotreatment of MBL with a conventional ALS drug, riluzole, further enhanced survival of motor neurons in this in-vitro ALS model. Our results show the potential use of MBL as a treatment for ALS and suggest a possible combination therapy strategy with other types of approved ALS drugs. |
| Databáze: | OpenAIRE |
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