Merkel Cell Carcinoma In Situ: No More Serendipity?
| Autor: | Deon Wolpowitz, Jag Bhawan, Candice E. Brem, Kyung Hee Chang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Dermatology Asymptomatic Pathology and Forensic Medicine Lesion Diagnosis Differential Biopsy medicine Neoplasm Humans integumentary system medicine.diagnostic_test Merkel cell carcinoma business.industry Papule General Medicine Middle Aged medicine.disease Carcinoma Merkel Cell medicine.anatomical_structure Pagetoid medicine.symptom business Merkel cell |
| Zdroj: | The American Journal of dermatopathology. 44(4) |
| ISSN: | 1533-0311 |
| Popis: | A 50-year-old man, with a history of extensive sun exposure and multiple previous non-melanoma skin cancers, presented with an asymptomatic 8-× 10-millimeter scaly, skin-colored papule on his right shoulder. Subsequent biopsy and excision revealed epidermal hyperplasia containing large atypical basaloid cells with pagetoid spread. Immunoperoxidase staining for cytokeratin-20 demonstrated a focal perinuclear dot-like pattern, and after excluding other in situ entities, a diagnosis of Merkel cell carcinoma In Situ (MCCIS) was rendered. MCCIS is a very rare entity. Although approximately 18% of Merkel cell carcinomas have epidermal involvement, currently only 17 cases of MCCIS have been reported, of which only 7 had no associated neoplasm. Previously, MCCIS was considered a serendipitous or incidental finding, as most cases co-existed with squamous cell carcinoma in situ. This case is unique in that it was not associated with a squamous lesion, and in addition, the pagetoid spread was unusual and has only occasionally been described. As such, MCCIS should be added to list of in situ epidermal lesions with pagetoid spread. |
| Databáze: | OpenAIRE |
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