The role of lysosomes in exercise-induced hepatic protein loss
| Autor: | G. L. Dohm, Hisham A. Barakat, P H Strausbauch, George J. Kasperek, D W Barnes, R. D. Snider |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1982 |
| Předmět: |
Male
History Time Factors Physical Exertion Phospholipid Vacuole Biology Education chemistry.chemical_compound Animals Glycogen Autophagy RNA Proteins Enzyme assay Computer Science Applications Cell biology Rats Cytosol Microscopy Electron Osmotic Fragility chemistry Liver Microsome biology.protein Lysosomes Research Article Subcellular Fractions |
| Popis: | Previous reports have shown that exercise causes a loss of liver protein. The purpose of the present study was to elucidate the mechanism of this exercise-induced protein loss. Exercise caused: (1) an increase in mechanical and osmotic lysosomal fragility; (2) a significant loss of hepatic water, glycogen, protein, phospholipid and RNA; (3) loss of protein from the soluble, mitochondrial and microsomal fractions: (4) loss of mitochondrial, microsomal and cytosolic, but not lysosomal, enzyme activity; (5) an increase in the number of autophagic vacuoles; (6) an increase in the lysosomal size. Taken together, these results suggest that the autophagolysosomal system is responsible for the exercise-induced hepatic protein loss. |
| Databáze: | OpenAIRE |
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