High effectiveness and safety of one-week antibiotic regimen in Helicobacter pylori eradication
| Autor: | R. Scagliarini, P. Pazzi, Giuliano Carli, S. Gamberini, Alberto Merighi, Sergio Gullini, M Dalla Libera |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Peptic Ulcer Antitrichomonal Agents Gastroenterology Endoscopy Gastrointestinal Tinidazole Helicobacter Infections Clarithromycin Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Omeprazole Antibacterial agent Aged Aged 80 and over Hepatology biology Helicobacter pylori business.industry Anti-ulcer Agent Stomach Middle Aged biology.organism_classification Anti-Ulcer Agents digestive system diseases Anti-Bacterial Agents Regimen medicine.anatomical_structure Duodenal Ulcer Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Alimentary pharmacologytherapeutics. 10(2) |
| ISSN: | 0269-2813 |
| Popis: | Background: Helicobacter pylori is strongly associated with peptic ulcer: H. pylori eradication markedly decreases the recurrence rate of duodenal and gastric ulcer, but the optimum length of antibiotic therapy in the eradication of H. pylori is still unclear. Aim: To verify the effectiveness and side-effect profile of an eradicating regimen consisting of omeprazole 20 mg daily for 4 weeks and, during the first week, combination antimicrobial treatment with tinidazole 500 mg b.d. plus clarithromycin 250 mg b.d. in patients with active duodenal and gastric ulcer. Methods: One hundred and ninety-six duodenal ulcer patients and 27 gastric ulcer patients with H. pylori infection were admitted into an open prospective study. Compliance was assessed by an accurate interview. Results: Overall, H. pylori was successfully eradicated in 201 of 223 patients (intention-to-treat 90.1%; 95% CI=85–94%): 176 of 196 duodenal ulcer patients became H. pylori-negative (89.8%; CI=85–94%) as well as 25 of 27 gastric ulcer patients (92.6%; CI=76–99%). Compliance was excellent in 221 of 223 (99.1%) patients evaluated as having taken all the medication as prescribed. Sixteen patients (7.2%) developed mild side effects during treatment. Conclusion: This combination treatment had excellent results with almost absolute compliance and a very low rate of minor side effects. |
| Databáze: | OpenAIRE |
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