Osteopenia, physical activity and health-related quality of life in survivors of brain tumors treated in childhood
| Autor: | William Furlong, Isaac Odame, Ronald D. Barr, Colin E. Webber, JoAnn Duckworth, Lesley F. Beaumont, Danielle Talsma |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Bone density Hormone Replacement Therapy medicine.medical_treatment Osteoporosis Physical exercise Motor Activity Body Mass Index Growth hormone deficiency Bone Density Internal medicine Prevalence medicine Humans Child Bone mineral Brain Neoplasms business.industry Lumbosacral Region Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Surgery Osteopenia Radiation therapy Bone Diseases Metabolic Oncology Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Quality of Life Female Cranial Irradiation business Body mass index |
| Zdroj: | Pediatric Blood & Cancer. 46:357-362 |
| ISSN: | 1545-5017 1545-5009 |
| DOI: | 10.1002/pbc.20512 |
| Popis: | Background Osteopenia has been reported in children surviving acute lymphoblastic leukemia and brain tumors, apparently as a consequence of therapy. It has been suggested that cranial irradiation may play a role in the development of this complication. In order to explore that possibility, we examined survivors of brain tumors treated with and without radiation in childhood to investigate associations between radiation, osteopenia, physical activity, health status and overall health-related quality of life (HRQL). Procedure Subjects were survivors of posterior fossa tumors (astrocytoma or medulloblastoma) or optic glioma, 1 year off treatment. Measurements of growth velocity, body composition, bone densitometry, physical activity and HRQL were undertaken. Results Twenty-five (62.5%) of the 40 eligible patients participated in the study. Of the 25 patients, 12 (48%) received radiation therapy (R group) while 13 received no radiation (NR group). Growth hormone (GH) deficiency had been detected in three subjects, one had completed GH therapy while two were still on hormone replacement. The prevalence of osteopenia was 44% in the entire group, and 67% versus 27% in the R and NR groups. Florid osteoporosis was present in 20% of the entire group, more than 40% of the R group but none of the NR group. A significant correlation (P |
| Databáze: | OpenAIRE |
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