Adjuvant role of radiation therapy for locally advanced laryngeal cancer without pathological lymph node metastasis

Autor:	Soon Yuhl Nam, Sang-wook Lee, Ji Won Kim, Minsu Kwon, Seung-Ho Choi, Jong-Lyel Roh, Sang Yoon Kim, Sung Hee Kim, Yoon Se Lee
Rok vydání:	2016
Předmět:	Adult Male Oncology medicine.medical_specialty medicine.medical_treatment Locally advanced Laryngectomy Lymph node metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Republic of Korea medicine Humans 030223 otorhinolaryngology Laryngeal Neoplasms Pathological Aged Retrospective Studies Aged 80 and over Adjuvant radiotherapy business.industry Head and neck cancer Cancer General Medicine Middle Aged medicine.disease Radiation therapy Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Neck Dissection Female Radiotherapy Adjuvant business Adjuvant
Zdroj:	Acta Oto-Laryngologica. 136:703-710
ISSN:	1651-2251 0001-6489
Popis:	Conclusion The application of adjuvant RT to reduce recurrence should be tailored in cases of pathologically negative node metastasis. Objectives The treatment modality following surgical resection of advanced laryngeal cancer is determined by adverse factors. Aside from lymph node metastasis (LNM) or positive margins, definite risk factors supporting adjuvant radiation therapy (RT) have not been clearly suggested. The aim of this study was to analyze the risk factors for advanced laryngeal cancer without LNM and the role of RT. Materials and methods Pathologically T3 and T4-staged laryngeal squamous cell carcinoma without LNM were reviewed. The patients were classified into RT (+) (n = 22) and RT (-) (n = 38) groups. Results Five-year overall survival (OS) of the RT (+) and RT (-) groups was 84.4% and 83.8%, respectively. Five-year disease-specific survival of the RT (+) and RT (-) groups was 88.4% and 93.9%. Five-year local control rate of the RT (+) and RT (-) groups was 94.7% and 91.3%. The factors affecting OS were smoking history and recurrence history (p = 0.02). By multivariate analysis, smoking history and recurrence history were determining factors for 5-year OS (p = 0.024 and p = 0.047, respectively).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657e76082d1372f778139846558a78a0 https://doi.org/10.3109/00016489.2016.1146827 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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