Feasibility of central cannabinoid CB1 receptor imaging with [124I]AM281 PET demonstrated in a schizophrenic patient
| Autor: | Kirsten R. Müller-Vahl, Frank Donnerstag, Wolfgang Brandau, Ralph Buchert, Georg Berding, Peter Gielow, Udo Schneider, Hinderk M. Emrich, Wolfram H. Knapp |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_treatment Morpholines Neuroscience (miscellaneous) Grey matter White matter Iodine Radioisotopes Receptor Cannabinoid CB1 Basal ganglia medicine Humans Radiology Nuclear Medicine and imaging Temporal cortex medicine.diagnostic_test Chemistry business.industry Brain Middle Aged Logan plot Psychiatry and Mental health medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Schizophrenia Feasibility Studies Pyrazoles Cannabinoid Nuclear medicine business Blood sampling |
| Zdroj: | Psychiatry research. 147(2-3) |
| ISSN: | 0165-1781 |
| Popis: | We studied central cannabinoid CB 1 receptors in a schizophrenic patient using the pyrazole derivative AM281 labelled with the positron-emitting nuclide iodine-124. A dynamic positron emission tomography (PET) acquisition with simultaneous blood sampling was performed up to 1.5 h post-injection. The classical Logan plot analysis was applied to generate a three-dimensional map of distribution volume (DV). The map was spatially normalised into the Montreal Neurological Institute stereotactic space. Using a volume of interest (VOI) template, mean values of DV were extracted from multiple grey matter regions and white matter (as a reference). As a measure of regional receptor availability, ratios of DV in grey matter to DV in white matter minus one (DVR−1) were calculated. The highest receptor binding was observed in the striatum and the pallidum (DVR−1: 0.35–0.37). Binding in basal ganglia regions was lower on the left than the right side. Moderately high binding was seen in the frontal cortex (0.22), the temporal cortex (0.18) and the cerebellum (0.15). In conclusion, 124 I-AM281 PET can be used to reveal areas with prominent CB 1 receptor binding. Nevertheless, limited image contrast and relatively high radiation exposure (physical half-life of 124 I: 4 days) have to be taken into account. Asymmetric receptor binding may possibly reflect pathologic changes in schizophrenia. |
| Databáze: | OpenAIRE |
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