Expression and localization of vascular endothelial growth factor and its receptor flt in pulmonary sarcoidosis
| Autor: | Edina Tolnay, Bruno Voss, Thorsten Wiethege, Cornelius Kuhnen, Klaus Michael Müller |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty medicine.medical_treatment Endothelial Growth Factors In situ hybridization Pathology and Forensic Medicine chemistry.chemical_compound Sarcoidosis Pulmonary Proto-Oncogene Proteins hemic and lymphatic diseases Macrophages Alveolar Humans Medicine RNA Messenger Receptor Molecular Biology In Situ Hybridization Aged Lymphokines Vascular Endothelial Growth Factor Receptor-1 Lung Vascular Endothelial Growth Factors business.industry Lymphokine Receptor Protein-Tyrosine Kinases Cell Biology General Medicine Macrophage Activation Middle Aged Vascular endothelial growth factor Vascular endothelial growth factor A Cytokine medicine.anatomical_structure chemistry Giant cell Female business |
| Zdroj: | Virchows Archiv. 432:61-65 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s004280050135 |
| Popis: | Vascular endothelial growth factor (VEGF) is a multifunctional cytokine, which has recently been reported to enhance the activation and migration of monocytes through the flt receptor in vitro, which are key events in granuloma formation of granulomatous disorders and in sarcoidosis. Since activated macrophages and monocytes are known to be involved in sarcoid granuloma formation in sarcoidosis, we investigated the expression of VEGF and its receptor flt in 33 paraffin-embedded lung tissue biopsies of patients with pulmonary sarcoidosis. VEGF-mRNA was localized by nonradioactive in situ hybridization, VEGF and flt expression were visualized immunohistochemically. We found an increased transcription and protein production of VEGF and an overexpression of flt in activated alveolar macrophages, in epitheloid cells, and in multinuclear giant cells of pulmonary sarcoid granulomas. |
| Databáze: | OpenAIRE |
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