KI Polyomavirus Detected in Respiratory Tract Specimens From Patients in St. Louis, Missouri
| Autor: | Richard S. Buller, Binh Minh Le, Max Q. Arens, Eugene Agapov, David J. Hormozdi, Gregory A. Storch |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Respiratory System Population Respiratory Syncytial Virus Infections Virus Immunocompromised Host Young Adult Internal medicine mental disorders medicine Humans Respiratory system Child education Respiratory Tract Infections Aged Aged 80 and over Polyomavirus Infections education.field_of_study Missouri business.industry Respiratory disease Infant Newborn Infant Retrospective cohort study Middle Aged medicine.disease Infectious Diseases medicine.anatomical_structure Child Preschool Respiratory Syncytial Virus Human Pediatrics Perinatology and Child Health Immunology Sputum Female Viral disease medicine.symptom Polyomavirus business Respiratory tract |
| Zdroj: | Pediatric Infectious Disease Journal. 29:329-333 |
| ISSN: | 0891-3668 |
| Popis: | Background: Studies have reported the presence of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) in respiratory secretions of young patients. So far, evidence has not supported a link between infections with either virus and respiratory tract disease; however, there has not been a large comparison of KIPyV-infected patients to age-matched patient groups. Methods: A retrospective study comparing clinical aspects of KIPyV-positive patients with respiratory syncytial virus (RSV)-positive, WUPyV-positive, and respiratory-virus negative patients. Using real-time polymerase chain reaction, 2599 respiratory samples from patients ranging from I day to 88 years of age were tested for KIPyV. Electronic medical records were reviewed for 65 cases, for a comparison group consisting of 195 patients negative for common respiratory viruses, and for 56 WUPyV-positive patients drawn from the same population. Twelve patients testing positive for KIPyV as the sole pathogen were matched to 36 RSV-positive patients and clinical features of both groups were compared. Results: Seventy-two (2.8%) respiratory samples were positive for KIPyV. Another virus was detected in 71 % of the KIPyV-positive samples. Analysis showed no statistically significant differences in clinical manifestations between KIPyV-positive patients and patients negative for common respiratory viruses, however, clinical characteristics of KIPyV-positive patients were less severe than those of patients positive for RSV. KIPyVpositive patients ≥3 years of age were usually immunocompromised in contrast to the younger children with KIPyV. Conclusions: This study did not demonstrate a link between KIPyV infection and symptomatic respiratory disease. Patients positive for KIPyV exhibited less severe clinical symptoms than patients positive for RSV. |
| Databáze: | OpenAIRE |
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