Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a)
| Autor: | Rune R. Frants, Dorret I. Boomsma, L.M. Havekes, Hans M.G. Princen, P. de Knijff, A. Kaptein |
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| Přispěvatelé: | Biological Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Apolipoprotein E
Male Netherlands Twin Register (NTR) medicine.medical_specialty Lipoproteins Locus (genetics) Biology chemistry.chemical_compound Apolipoproteins E Internal medicine Genetic variation medicine Humans Allele Alleles Genetics Polymorphism Genetic Cholesterol Lipoprotein(a) Cholesterol LDL Middle Aged Endocrinology Phenotype chemistry Low-density lipoprotein biology.protein Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | de Knijff, P, Kaptein, A, Boomsma, D I, Princen, H M G, Frants, R R & Havekes, L 1991, ' Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a) ', Atherosclerosis, vol. 90, no. 2-3, pp. 169-174 . https://doi.org/10.1016/0021-9150(91)90111-F Atherosclerosis, 90(2-3), 169-174. Elsevier Ireland Ltd |
| ISSN: | 0021-9150 |
| Popis: | In a group of 303 healthy Caucasian adults of both sexes we studied the influence of the apolipoprotein E (apo E) polymorphism on plasma levels of Lipoprotein(a) (Lp(a)). The APOE ∗ 2 allele was found to decrease the mean plasma Lp(a) level by 24.8%, whereas the APOE ∗ 4 allele increased the mean Lp(a) level by 25.7%. These effects were parallel to the effect of apo E polymorphism on plasma cholesterol and low density lipoprotein (LDL)-cholesterol. For the Lp(a) levels, the genetic variance associated with the APOE locus contributed about 4% to the total phenotypic variance. For plasma cholesterol and LDL-cholesterol this contribution was 4.5 and 6.3%, respectively. We also found a significant positive correlation between LDL-cholesterol and Lp(a) levels. Since the apo E polymorphism effects LDL-receptor activity, we conclude that, at least in healthy normolipidemic individuals, plasma levels of Lp(a) are modulated by the LDL-receptor activity. |
| Databáze: | OpenAIRE |
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