In Vitro Inhibition of Rabbit and Guinea Pig Erythrocyte Acetylcholinesterase by Soman
| Autor: | J. Bajgar, J. Kassa |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Lagomorpha
biology General Medicine Pharmacology Toxicology biology.organism_classification Acetylcholinesterase Guinea pig chemistry.chemical_compound Red blood cell medicine.anatomical_structure Biochemistry chemistry Enzyme inhibitor Soman biology.protein medicine Butyrylcholinesterase Cholinesterase |
| Zdroj: | Toxicology in Vitro. 13:403-408 |
| ISSN: | 0887-2333 |
| DOI: | 10.1016/s0887-2333(99)00009-0 |
| Popis: | Guinea pig and rabbit erythrocytes were incubated with a high concentration of soman to achieve zero acetylcholinesterase activity. After washing with saline, the erythrocytes were incubated with horse plasma butyrylcholinesterase. The inhibition of plasma butyrylcholinesterase activity was observed because of inhibitor release from the erythrocytes. This release was quantified and found to be the highest after 30 min of incubation. Our results confirm that erythrocytes can serve as a depot for soman and make it possible to lengthen its toxic effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect