Movement disorders are associated with schizotypy in unaffected siblings of patients with non-affective psychosis
| Autor: | Wiepke Cahn, Diederik E. Tenback, Jeroen P. F. Koning, P. N. van Harten, René S. Kahn, Meinte G. Vollema |
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| Přispěvatelé: | Psychiatrie & Neuropsychologie, RS: MHeNs School for Mental Health and Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Movement disorders Adolescent Schizotypy schizotypy Neuropsychological Tests Akathisia Schizotypal Personality Disorder Young Adult medicine Humans risk factors Genetic Predisposition to Disease Psychiatry Applied Psychology siblings Netherlands Dystonia Psychiatric Status Rating Scales business.industry psychosis risk Middle Aged medicine.disease schizophrenia Psychiatry and Mental health Cross-Sectional Studies Dyskinesia Psychotic Disorders Schizophrenia Case-Control Studies Female Abnormal Involuntary Movement Scale medicine.symptom business |
| Zdroj: | Psychological Medicine, 41(10), 2141-2147. Cambridge University Press |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundMovement disorders and schizotypy are both prevalent in unaffected siblings of patients with schizophrenia and both are associated with the risk of developing psychosis or schizophrenia. However, to date there has been no research into the association between these two vulnerability factors in persons with an increased genetic risk profile. We hypothesized that unaffected siblings of patients with non-affective psychosis have more movement disorders and schizotypy than healthy controls and that these co-occur.MethodIn a cross-sectional design we assessed the prevalence and inter-relationship of movement disorders and schizotypy in 115 unaffected siblings (mean age 27 years, 44% males) and 100 healthy controls (mean age 26 years, 51% males). Movement disorders were measured with the Abnormal Involuntary Movement Scale (AIMS), the Unified Parkinson Disease Rating Scale (UPDRS), the Barnes Akathisia Rating Scale (BARS), and one separate item for dystonia. Schizotypy was assessed with the Structured Interview for Schizotypy – Revised (SIS-R).ResultsThere were significant differences in the prevalence of movement disorders in unaffected siblings versus healthy controls (10% v. 1%, pp=0.02 and 0.03 respectively) than those without. In addition, dyskinesia correlated with positive schizotypy (r=0.51, p=0.02).ConclusionsThe association between movement disorders (dyskinesia in particular) with positive and total schizotypy in unaffected siblings suggests that certain vulnerability factors for psychosis or schizophrenia cluster in a subgroup of subjects with an increased genetic risk of developing the disease. |
| Databáze: | OpenAIRE |
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