Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users
| Autor: | Jin Li, Rong Gui, Min-Zhu Huang, Xia Chen, Deng-Qing Li, Xin-min Nie, Lan Guan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Therapeutic effects Allyl compound Cryptosporidium Cryptosporidiosis Placebo Article lcsh:Infectious and parasitic diseases law.invention Drug Users Drug user Young Adult Randomized controlled trial Acquired immunodeficiency syndrome (AIDS) law Internal medicine Spiramycin medicine Humans lcsh:RC109-216 Pharmacology (medical) Disulfides Young adult Pharmacology biology business.industry Therapeutic effect biology.organism_classification medicine.disease Garlicin Allyl Compounds Infectious Diseases Acetylspiramycin Immunology Coccidiostats Parasitology business |
| Zdroj: | International Journal for Parasitology: Drugs and Drug Resistance International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 185-190 (2015) |
| ISSN: | 2211-3207 |
| DOI: | 10.1016/j.ijpddr.2015.09.002 |
| Popis: | Cryptosporidiosis affects humans of all ages, particularly malnourished children and those with compromised immune systems such as HIV/AIDS. This study investigated the therapeutic effects of acetylspiramycin and garlicin on Cryptosporidium infection in institutionalized male drug users receiving rehabilitative treatment. Examination of stool specimens from 903 drug users via modified acid-fast bacilli staining resulted in 172 positive cases. Among them 151 subjects consented to participate in a randomized trial of acetylspiramycin and garlicin in four groups: acetylspiramycin plus garlicin, acetylspiramycin only, garlicin only, and placebo control. The cryptosporidiosis rate was higher in younger subjects with longer drug use history than subjects who are older with shorter history of drug use. After two segments of treatments, 76.2% of the cases achieved negative test results, with the four groups achieving the rates of 92.1%, 76.7%, 72.2%, and 61.8%, respectively (χ2 = 9.517, P = 0.023). These results indicate clinical potential of garlicin in conjunction with acetylspiramycin in treating cryptosporidiosis. Graphical abstract Highlights • Randomized trial in Cryptosporidium positive drug users in China. • Positive correlation found between the cryptosporidiosis rate and the drug addicting years. • Clinical potential of garlicin in conjunction with acetylspiramycin in treating cryptosporidiosis. |
| Databáze: | OpenAIRE |
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