Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses
| Autor: | Tom Mariën, Bert Seys, Gabriele Braun, K. Hellmann, Edouard Adriaensen, Jan H. Spaas, Marc Suls, Lore Van Hecke, Sarah Broeckx, Jeroen Declercq, Aurélie Vandenberghe |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology Disease Osteoarthritis PLATELET-RICH PLASMA Injections Intra-Articular 0302 clinical medicine allogeneic Hematology Allografts Clinical Trial horse medicine.anatomical_structure Lameness Female Joint Diseases REPEATABILITY arthrosis medicine.medical_specialty BONE-MARROW Biology Mesenchymal Stem Cell Transplantation IMMUNOMODULATORY PROPERTIES CLINICAL-TRIAL SUBJECTIVE EVALUATION MSC 03 medical and health sciences field trial Double-Blind Method Internal medicine medicine INTRAARTICULAR INJECTION Animals Veterinary Sciences Horses Mesenchymal stem cell Mesenchymal Stem Cells Cell Biology Chondrogenesis medicine.disease GCP MODEL 030104 developmental biology OSTEOARTHRITIS Platelet-rich plasma LAMENESS Horse Diseases Bone marrow human activities 030217 neurology & neurosurgery Developmental Biology Follow-Up Studies |
| Zdroj: | Stem Cells and Development STEM CELLS AND DEVELOPMENT |
| ISSN: | 1557-8534 1547-3287 |
| Popis: | Degenerative joint disease is one of the main causes of equine early retirement from pleasure riding or a performance career. The disease is initially triggered by an abnormal loading of normal cartilage or a normal loading of abnormal cartilage. This primary insult is accompanied with joint inflammation, which leads to further progressive degeneration of the articular cartilage and changes in the surrounding tissues. Therefore, in search for an effective treatment, 75 adult horses with early signs of degenerative fetlock joint disease were enrolled in a randomized, multicenter, double-blinded, and placebo-controlled study. Fifty animals were injected intra-articularly with the investigational veterinary product (IVP) consisting of allogeneic chondrogenic induced mesenchymal stem cells (ciMSCs) with equine allogeneic plasma, and 25 horses were injected with 0.9% NaCl (saline) control product. From week 3 to 18 after treatment, lameness scores (P |
| Databáze: | OpenAIRE |
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