Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling
| Autor: | Jm, Kneller, Ehlen T, Jp, Matisic, Miller D, Van Niekerk D, Wl, Lam, Marra M, Richards-Kortum R, Follen M, Calum MacAulay, Sj, Jones |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
0301 basic medicine
Pharmacology lcsh:R5-920 cervical cancer Biochemistry (medical) 3. Good health 03 medical and health sciences optical imaging 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Molecular Medicine biomarker longSAGE lcsh:Medicine (General) Original Research |
| Zdroj: | Biomarker Insights, Vol 2, Pp 447-461 (2007) ResearcherID Europe PubMed Central Biomarker Insights |
| ISSN: | 1177-2719 |
| Popis: | Sixteen longSAGE libraries from four different clinical stages of cervical intraepithelial neoplasia have enabled us to identify novel cell-surface biomarkers indicative of CIN stage. By comparing gene expression profiles of cervical tissue at early and advanced stages of CIN, several genes are identified to be novel genetic markers. We present fifty-six cell-surface gene products differentially expressed during progression of CIN. These cell surface proteins are being examined to establish their capacity for optical contrast agent binding. Contrast agent visualization will allow real-time assessment of the physiological state of the disease process bringing vast benefit to cancer care. The data discussed in this publication have been submitted to NCBIs Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/ ) and are accessible through GEO Series accession number GSE6252. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|