Angiotensin-Converting Enzyme Inhibitor Reduces Radiation-Induced Periprosthetic Capsular Fibrosis
| Autor: | Serhan Tuncer, Ozge Petek Erpolat, Çiğdem Elmas, Volkan Demircan, Omer Polat, Ozlem Gulbahar, Ertugrul Senturk, Burak Pasinlioglu, Sanem Saribas, Serap Catli Dinc |
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| Rok vydání: | 2020 |
| Předmět: |
Ramipril
Male medicine.medical_specialty Breast Implants Urology Periprosthetic Angiotensin-Converting Enzyme Inhibitors Breast Neoplasms Silicone Gels 03 medical and health sciences 0302 clinical medicine Fibrosis Implant Capsular Contracture Medicine Animals Humans Breast Breast Implantation Mastectomy biology business.industry Angiotensin-converting enzyme Capsular contracture medicine.disease Rats Radiation Injuries Experimental 030220 oncology & carcinogenesis ACE inhibitor biology.protein 030211 gastroenterology & hepatology Surgery Female Radiotherapy Adjuvant Implant Contracture medicine.symptom business medicine.drug |
| Zdroj: | The Journal of surgical research. 263 |
| ISSN: | 1095-8673 |
| Popis: | Background The capsular contracture is one of the main complications after radiotherapy in patients with implant-based reconstruction. The aim of this study is to evaluate the efficacy of ramipril for the prevention of radiation-induced fibrosis around the silicone implant. Materials and methods Thirty Wistar rats in 5 groups were used. Group 1: implant; group 2: implant + radiation; group 3: ramipril + implant; group 4: ramipril + implant + radiation; group 5: sham. Ramipril treatment was started 5 d before surgery and continued for 12 wk after surgery. A mini silicone implant was placed in the back of the rats. A single fraction of 21.5 Gy radiation was applied. Tissues were examined histologically and immunohistochemically (TGF-β1, MMP-2, and TIMP-2 expression). The alteration of plasma TGF-β1 levels was examined before and after the experiment. Results After applying implant or implant + radiation, capsular thickness, percentage of fibrotic area, tissue and plasma TGF-β1 levels significantly increased, and MMP-2/TIMP-2 ratio significantly decreased compared with the sham group. In ramipril-treated groups, the decrease in capsular thickness, fibrosis, TGF-β1 positivity, and an increase in MMP-2/TIMP-2 ratio were found significant. In the ramipril + implant + radiation group, the alteration values of TGF-β1 dramatically decreased. Conclusions Our results show that ramipril reduces radiation-induced fibrosis and contracture. The results of our study may be important for the design of the clinical trials required to investigate the effective and safe doses of ramipril, which is an inexpensive and easily tolerated drug, on humans. |
| Databáze: | OpenAIRE |
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