Palladium(II)-Catalyzed Intramolecular C–H Alkenylation for the Synthesis of Chromanes

Autor:	Nuria Sotomayor, Alexander Misol, Marcos Gómez-Redondo, Asier Carral-Menoyo, Esther Lete
Rok vydání:	2019
Předmět:	010405 organic chemistry Chemistry Aryl Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Intramolecular force Moiety Palladium
Zdroj:	The Journal of Organic Chemistry. 84:2048-2060
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.8b03051
Popis:	The intramolecular Pd(II)-catalyzed alkenylation of aryl homoallyl ethers constitutes a mild, versatile, and efficient procedure for the synthesis of highly and diversely substituted chromanes and 2 H-chromenes. The use of p-TsOH as an additive allows more efficient reactions that could be carried out a room temperature in most cases. The procedure has a wide scope, allowing the synthesis of alkylidenechromanes and 2 H-chromenes substituted at C-2 or C-3 of the chromene moiety, thus accessing relevant flavenes and isoflavenes, and even coumarins, in high yields (59 to 91%, 32 examples).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6575bc0c0b633df071073a4f261fbbab https://doi.org/10.1021/acs.joc.8b03051 Zobrazit plný text záznamu