Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury

Autor:	Anna Kosik, Attila Szabo, Andrea Fekete, Rózsa Csohány, Leonóra Balicza-Himer, Domonkos Pap, Ádám Vannay, Erna Sziksz, Ágnes Prókai, Dániel Sugár, Katalin Kis-Petik
Rok vydání:	2016
Předmět:	Male medicine.medical_specialty 030232 urology & nephrology Ischemia 030204 cardiovascular system & hematology Kidney Flow cytometry Renin-Angiotensin System 03 medical and health sciences 0302 clinical medicine Sex Factors In vivo Internal medicine Renin–angiotensin system Renin medicine Animals Rats Wistar Transplantation medicine.diagnostic_test Renal ischemia business.industry medicine.disease Flow Cytometry Angiotensin II Kidney Transplantation Capillaries Rats Vasodilation Endocrinology Microscopy Fluorescence Vasoconstriction Reperfusion Injury Pediatrics Perinatology and Child Health Female medicine.symptom business Reperfusion injury Biomarkers
Zdroj:	Pediatric transplantation. 20(5)
ISSN:	1399-3046
Popis:	Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two genders during ischemia/reperfusion injury. In male and female Wistar rats, renal ischemia was induced followed by a reperfusion period of two, eight, 16, 24, or 48 h. We applied flow cytometry to measure renin content and multiphoton imaging to visualize renin granules and changes of peritubular diameters in vivo during ischemia/reperfusion. Renin content decreased in CD in the first eight h of reperfusion; however, after 16 h, its amount increased. In males, the production of renin was more pronounced, and the duration of vasoconstriction was longer with a subsequent phase of vessel hyperdilation compared to females. Renal ischemia/reperfusion injury induces renin response not only in the JGA, but also in the CD segment. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain the different dynamism of renal vessel regulation between the two genders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657582ed628677027a215b70e408a2a4 https://pubmed.ncbi.nlm.nih.gov/27090360 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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