Volatile organic compounds in asthma diagnosis: a systematic review and meta-analysis
| Autor: | André Moreira, J. Cavaleiro Rufo, E. Oliveira Fernandes, Joana Madureira |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Immunology Sensitivity and Specificity Severity of Illness Index 01 natural sciences Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Internal medicine Threshold effect Odds Ratio medicine Humans Immunology and Allergy Asthma Volatile Organic Compounds business.industry 010401 analytical chemistry Area under the curve External validation Odds ratio Publication bias medicine.disease 0104 chemical sciences 030228 respiratory system Exhalation Meta-analysis business Publication Bias Biomarkers Systematic search |
| Zdroj: | Allergy. 71:175-188 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.12793 |
| Popis: | We aimed to assess the value and classification rate of exhaled volatile organic compounds (VOCs) in asthma diagnosis. A PRISMA-oriented systematic search for published studies regarding exhaled VOCs in asthma diagnosis was conducted based on predefined criteria. Studies presenting sensitivity and specificity values for the test were included in the meta-analysis. Pooled diagnosis odds ratios (DOR), area under the curve (AUC) and positive and negative likelihood ratios (LR) for exhaled VOC profiles were calculated; and publication bias, threshold effect and heterogeneity were estimated. Eighteen studies were selected for the qualitative analysis and six met the criteria for inclusion in the quantitative analysis. Mean (95% CI) pooled DOR, positive and negative LR were 49.3 (15.9-153.3), 5.86 (3.07-11.21) and 0.16 (0.10-0.26), respectively. The AUC value was 0.94. Only three of the 18 reviewed studies performed an external validation of the model using a different data set. The results from the revised studies suggest that exhaled VOCs are promising biomarkers for asthma diagnosis and that several compounds, mainly alkanes, may be significantly associated with asthma inflammation. However, there are still various constraints associated with standardization and externally validated studies are needed to introduce exhaled VOC profiling in a clinical scenario. |
| Databáze: | OpenAIRE |
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