l-Arginine supplementation blunts resistance exercise improvement in rats with chronic kidney disease
| Autor: | Clarice Kazue Fujihara, Michel Kendy Souza, Niels Olsen Saraiva Câmara, Rodrigo Vanerson Passos Neves, Simone A. Teixeira, Marcelo Nicolas Muscará, Anderson Sola Haro, Clévia Santos Passos, Alvaro Pacheco e Silva Filho, Thiago Santos Rosa, Simone Costa Alarcon Arias, Marcos Antonio Cenedeze, Milton Rocha Moraes |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Arginine medicine.medical_treatment Population Urology Renal function urologic and male genital diseases Kidney 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Physical Conditioning Animal Renal fibrosis Medicine Animals Muscle Strength General Pharmacology Toxicology and Pharmaceutics Rats Wistar Renal Insufficiency Chronic education Muscle Skeletal education.field_of_study business.industry Resistance Training General Medicine medicine.disease Fibrosis Nephrectomy Rats Arginase Oxidative Stress 030104 developmental biology Sarcopenia Dietary Supplements Disease Progression Cytokines business Kidney disease |
| Zdroj: | Life sciences. 232 |
| ISSN: | 1879-0631 |
| Popis: | Chronic kidney disease (CKD) patients present L-arginine (L-arg) deficiency and L-arg supplementation has been used as a treatment. In addition, sarcopenia is another common problem in CKD population, resistance training (RT) is one of the conservative strategies developed to prevent CKD progression, and however there are no evidences of a combination of these two strategies to treat CKD outcomes. The aim of this study was to evaluate the effects of oral L-arg supplementation combined with RT in an experimental model of CKD. Twenty-five Munich-Wistar male rats, 8-week-old were divided in 5 groups: Sham (sedentary control), Nx (CKD sedentary), Nx L-arg (CKD sedentary supplemented with 2% of L-arg), Nx RT (CKD exercised) Nx RT + L-arg (CKD exercised and supplemented with 2% of L-arg). CKD model was obtained by a subtotal 5/6 nephrectomy. RT was performed on a ladder climbing, three weekly sessions on non-consecutive days, with an intensity of 70% maximum carrying capacity. They were submitted to RT and/or L-arg supplementation for 10 weeks. There was a significant improvement in muscle strength, renal function, anti-inflammatory cytokines, arginase metabolism and renal fibrosis after RT. However, the combination of RT and L-arg impaired all the improvements promoted by RT alone. The L-arg supplementation alone did not impair renal fibrosis and renal function. In conclusion, RT improved inflammatory balance, muscle strength, renal function and consequently decreased renal fibrosis. Nevertheless, the association with L-arg supplementation prevented all these effects promoted by RT. |
| Databáze: | OpenAIRE |
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