Vitamin D deficiency, impaired lung function and total and respiratory mortality in a cohort of older men: cross-sectional and prospective findings from The British Regional Heart Study
| Autor: | S Goya Wannamethee, Paul Welsh, Olia Papacosta, Lucy Lennon, Peter Whincup |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
Male Epidemiology Vital Capacity General Medicine Middle Aged respiratory system Vitamin D Deficiency respiratory tract diseases Pulmonary Disease Chronic Obstructive Cross-Sectional Studies Spirometry Forced Expiratory Volume respiratory medicine (see thoracic medicine) Humans Prospective Studies Vitamin D Lung nutrition & dietetics Aged |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesVitamin D deficiency is associated with chronic obstructive pulmonary disease (COPD). We examined the cross-sectional association between 25-hydroxyvitamin D (25(OH)D) and lung function impairment and assessed whether vitamin D deficiency is related to long-term mortality in those with impaired lung function.DesignProspective studySettingGeneral practices in the UK.Participants3575 men aged 60–79 years with no prevalent heart failure.Outcome measuresAirway obstruction and mortality. The Global Initiative on Obstructive Lung diseases (GOLD) spirometry criteria was used to define airway obstruction.ResultsDuring the follow-up period of 20 years, there were 2327 deaths (114 COPD deaths). Vitamin D deficiency was defined as serum 25(OH)D levels20 ng/mL. In cross-sectional analysis, vitamin D deficiency was more prevalent in those with moderate COPD (FEV/FVC 1 50 to 1, forced expiratory volume in 1 s and FVC, forced vital capacity) and severe COPD (FEV/FVC 1 1>80%) or restrictive lung disease (FEV1/FVC >70% and FVC =20 ng/mL were 1.39 (1.10 to 1.75), 1.52 (1.17 to 1.98), 1.58 (1.17 to 2.14) and 1.39 (0.83 to 2.33) for those with no lung impairment, restrictive lung function, mild/moderate COPD and severe COPD, respectively.ConclusionMen with COPD were more likely to be vitamin D deficient than those with normal lung function. Vitamin D deficiency is associated with increased all-cause mortality in older men with no lung impairment as well as in those with restrictive or obstructive lung impairment. |
| Databáze: | OpenAIRE |
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