Cardiovascular sequelae in long-term survivors of young peoples’ cancer: a linked cohort study
| Autor: | Chris P Gale, Richard G. Feltbower, David T. Bowen, Steven E. Oliver, M van Laar, Adam Glaser |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Risk Gerontology Cancer Research Pediatrics medicine.medical_specialty Adolescent Short Communication Cohort Studies Young Adult Neoplasms medicine late effects Humans Young adult Child childhood business.industry cardiovascular Incidence Incidence (epidemiology) Infant Newborn survivors Infant Cancer social sciences medicine.disease Infant newborn humanities England Oncology Cardiovascular Diseases Child Preschool population characteristics Female business teenage human activities Cohort study |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2014.37 |
| Popis: | Background: We aimed to define the incidence and risk of cardiovascular late effects (LEs) identified from inpatient hospital episode statistics (HES) among long-term survivors of cancer in young people by age at diagnosis (0–14 and 15–29 years). Methods: Records from the Yorkshire Specialist Register of Cancer in Children and Young People (1991–2006) were linked to inpatient HES data (1996–2011) to assess rates of cardiovascular LEs. Rates were compared with the general population in Yorkshire using age–sex-matched HES records for the entire region. Results: Of 3247 survivors of cancer, 3.6% had at least one cardiovascular LE. Overall, cardiovascular hospitalisations for the childhood cohort were threefold higher compared with the general population, but did not differ for young adults. For young adults, increased rates were limited to pericardial disease, cardiomyopathy and heart failure, pulmonary heart disease, hypertension and conduction disorders. Conclusions: Survivors of childhood and young adult cancer remain at increased risk of cardiovascular LEs compared with the general population. |
| Databáze: | OpenAIRE |
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