Dopaminergic control of aldosterone secretion is not mediated by atrial natriuretic factor in patients with essential hypertension
| Autor: | Paola Ferraris, Alberto Morganti, Alberto Zanchetti, Giorgio Ardeleani, Carla Sala, Patrizia Quorso, Bruno Ambrosi, Paolo Venegoni |
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| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Metoclopramide Physiology Dopamine Essential hypertension Plasma renin activity chemistry.chemical_compound Internal medicine Ibopamine otorhinolaryngologic diseases Internal Medicine medicine Humans Aldosterone business.industry Dopaminergic medicine.disease Prolactin Deoxyepinephrine Endocrinology chemistry Hypertension cardiovascular system Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0952-1178 |
| Popis: | Both dopamine and atrial natriuretic factor (ANF) are known to suppress aldosterone secretion. Since it is possible that dopaminergic mechanisms facilitate ANF release, we investigated the relationship between these two inhibitory systems by comparing the increases in aldosterone induced by metoclopramide, a dopaminergic antagonist, with decreases in ANF. Aldosterone, ANF, prolactin, plasma renin activity, cortisol and potassium were measured before and after the intravenous injection of 10 mg metoclopramide, blood samples being collected at 15-min intervals up to 2 h after the injection. These studies were performed in patients with essential hypertension who were maintained on a constant sodium intake (100 mmol/day), before and after 5 days of treatment with ibopamine, an orally active dopamine analogue. Before ibopamine metoclopramide induced the expected, marked increases in aldosterone and in prolactin, but only minimal, non-significant decreases in ANF. All other humoral parameters, as well as blood pressure and heart rate, were unaffected by metoclopramide. After ibopamine treatment, which caused a transient natriuretic effect, the responses of aldosterone and of ANF to metoclopramide were similar to those observed in control studies, whereas that of prolactin was enhanced. Thus, it appears that the suppressive effect exerted by the dopaminergic tone on aldosterone secretion is independent of ANF both before and after dopaminergic stimulation. |
| Databáze: | OpenAIRE |
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