Consumption of a High Fat Diet Impairs Reproductive Performance in Sprague-Dawley Rats
| Autor: | Kathleen M. Rasmussen, Tami R. Myers, Maureen A. Shaw |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Litter (animal)
medicine.medical_specialty media_common.quotation_subject Medicine (miscellaneous) Cafeteria Biology Rats Sprague-Dawley Animal science Pregnancy Internal medicine Lactation medicine Animals Fetal Death Ovulation media_common Nutrition and Dietetics Body Weight medicine.disease biology.organism_classification Dietary Fats Obesity Rats Endocrinology medicine.anatomical_structure Fertilization Gestation Female medicine.symptom Weight gain |
| Zdroj: | The Journal of Nutrition. 127:64-69 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/127.1.64 |
| Popis: | Rats made obese by cafeteria feeding have poor reproductive outcomes. To investigate this phenomenon in animals fed a more nutritionally adequate diet, female rats were fed either a high fat (HF) (modified AIN-76A, 35 g fat/100 g diet) or a control (C) (AIN-76A, 5 g fat/100 g diet), diet, beginning at 27 d of age. To assess reproductive performance, rats were studied at d 0, 5 and 18 of pregnancy and on d 3 of lactation. Pregnancy rates were significantly (P < 0.001) lower in the high fat-fed rats than in the control-fed rats (56.4 and 89.1%, respectively). There was no difference between groups in total pregnancy weight gain or the proportion of weight gained during pregnancy that was retained by the dam. High fat-fed dams tended to gain weight more rapidly early in gestation than control-fed dams and then less rapidly than control-fed dams during the last week of gestation. Litter number and pup weight at birth did not differ between groups, but of high fat-fed pups had significantly higher (P < 0.04) mortality rates than pups of control-fed dams (16.5 and 7.7%, respectively) over the first 3 d of life. Control-fed dams experienced the expected reduction (P < 0.05) in plasma insulin concentrations between the end of pregnancy and early lactation, but high fat-fed dams did not. Thus, physiological mechanisms controlling distribution of metabolic fuels may not be functioning properly in high fat-fed dams. Therefore, consuming a high fat diet reduces a rat's capacity to conceive and ability to maintain her litter during the perinatal period. |
| Databáze: | OpenAIRE |
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