Homeostatic circuits selectively gate food cue responses in insular cortex
| Autor: | Rohan N. Ramesh, Bradford B. Lowell, Henning Fenselau, Joseph C. Madara, Glenn J. Goldey, Jon M. Resch, Kirsten M. Levandowski, Christian R. Burgess, Nick Jikomes, Mark L. Andermann, Yoav Livneh, Veronica E. Diaz |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Hunger media_common.quotation_subject Hypothalamus Insular cortex Satiety Response 03 medical and health sciences Mice 0302 clinical medicine Neuroimaging Perception Neural Pathways medicine Animals Homeostasis Agouti-Related Protein Sensory cue media_common Cerebral Cortex Neurons Multidisciplinary digestive oral and skin physiology Peptide Fragments Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Cerebral cortex Food Cues Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Photic Stimulation Basolateral amygdala |
| Zdroj: | Nature. 546(7660) |
| ISSN: | 1476-4687 |
| Popis: | Physiological needs bias perception and attention to relevant sensory cues. This process is 'hijacked' by drug addiction, causing cue-induced cravings and relapse. Similarly, its dysregulation contributes to failed diets, obesity, and eating disorders. Neuroimaging studies in humans have implicated insular cortex in these phenomena. However, it remains unclear how 'cognitive' cortical representations of motivationally relevant cues are biased by subcortical circuits that drive specific motivational states. Here we develop a microprism-based cellular imaging approach to monitor visual cue responses in the insular cortex of behaving mice across hunger states. Insular cortex neurons demonstrate food-cue-biased responses that are abolished during satiety. Unexpectedly, while multiple satiety-related visceral signals converge in insular cortex, chemogenetic activation of hypothalamic 'hunger neurons' (expressing agouti-related peptide (AgRP)) bypasses these signals to restore hunger-like response patterns in insular cortex. Circuit mapping and pathway-specific manipulations uncover a pathway from AgRP neurons to insular cortex via the paraventricular thalamus and basolateral amygdala. These results reveal a neural basis for state-specific biased processing of motivationally relevant cues. |
| Databáze: | OpenAIRE |
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