PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description
| Autor: | Janne Boone-Heinonen, Jiang Bian, Jenny Ingber, L. Charles Bailey, Matthew W. Gillman, Arthur J. Davidson, Lara R. Dugas, Juliane S. Reynolds, Casie Horgan, Andrew L. Brickman, Douglas Lunsford, Carmen R. Isasi, Elyse O. Kharbanda, Jason P. Block, Hanieh Razzaghi, Amanda F. Dempsey, Stephanie L. Fitzpatrick, Xiaobo Zhou, Prakash Nadkarni, William J. Heerman, Goutham Rao, Iben M. Ricket, Jeffrey J. VanWormer, Doug Kane, Zachary Willis, Maria Rayas, Mary Jo Messito, Kevin O'Bryan, Melanie Jay, Bradley K. Taylor, Ihuoma Eneli, Christopher B. Forrest, Tim Wysocki, Holly L. Peay, Marc B. Rosenman, Alfredo Tirado-Ramos, Lauren P. Cleveland, David O. Meltzer, Daksha Ranade, Robert M. Siegel, Daniel S. Hsia, Michael A. Horberg, Elsie M. Taveras, Jessica L. Sturtevant, David M. Janicke, Jon Puro, Veeral N. Tolia, Brad Appelhans, William G. Adams, Tony Solomonides, Matthew F. Daley, Jonathan A. Finkelstein |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Percentile Overweight Article Childhood obesity Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Patient-Centered Care 030225 pediatrics Humans Medicine Longitudinal Studies 030212 general & internal medicine Child business.industry Body Weight Infant medicine.disease Obesity Body Height Drug Utilization United States Anti-Bacterial Agents Clinical research Child Preschool Pediatrics Perinatology and Child Health Cohort Female Observational study medicine.symptom business Body mass index |
| Zdroj: | Acad Pediatr |
| ISSN: | 1876-2859 |
| DOI: | 10.1016/j.acap.2018.02.008 |
| Popis: | OBJECTIVES: The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using healthcare data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet’s inaugural observational studies. The objectives of this manuscript are to describe (1) the processes used to integrate and analyze data from children across 36 participating institutions and (2) the cohort characteristics and prevalence of antibiotic use. METHODS: We included children in the cohort if they had at least one same-day height and weight measured in each of three age periods: 1) before 12 months, 2) 12 to 30 months, and 3) after 24 months. We distributed statistical queries that each institution ran on its local version of the PCORnet Common Data Model, with aggregate data returned for analysis. We defined overweight or obesity as age-sex-specific body mass index ≥ 85(th), obesity ≥95(th) percentile, and severe obesity ≥120% of the 95(th) percentile. RESULTS: 681,739 children met the cohort inclusion criteria and were racially/ethnically diverse (24.9% black, 17.5% Hispanic). Before 24 months, 55.2% of children received at least one antibiotic prescription; 21.3% received a single antibiotic prescription, 14.3% received four or more, and 33.3% received a broad spectrum antibiotic. Overweight and obesity prevalence was 27.6% at 4 to |
| Databáze: | OpenAIRE |
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