End-tidal CO2 response to low levels of inspired CO2 in awake beagle dogs
| Autor: | D. M. Stavert, P. Reischl, B. J. O'Loughlin, L. C. Murdock, S. M. Lewis |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Physiology Beagle pCO2 Hypercapnia Dogs Physiology (medical) medicine Tidal Volume Animals Respiratory mask Lung Chemistry respiratory system Carbon Dioxide Chemoreceptor Cells respiratory tract diseases Control of respiration Anesthesia Breathing Female medicine.symptom Blood Gas Analysis Airway Lung Volume Measurements circulatory and respiratory physiology End tidal co2 |
| Zdroj: | Journal of applied physiology: respiratory, environmental and exercise physiology. 48(6) |
| ISSN: | 0161-7567 |
| Popis: | The steady-state end-tidal CO2 tension (PCO2) was examined during control and 1% CO2 inhalation periods in awake beagle dogs with an intact airway breathing through a low dead-space respiratory mask. A total of eight experiments were performed in four dogs, comprising 31 control observations and 23 CO2 inhalation observations. The 1% inhaled CO2 produced a significant increase in the steady-state end-tidal PCO2 comparable to the expected 1 Torr predicted from conventional CO2 control of ventilation. We conclude that 1% inhaled CO2 results in a hypercapnia. Any protocol that is to resolve the question of whether mechanisms are acting during low levels of inhaled CO2 such that ventilation increases without any change in arterial PCO2 must have sufficient resolving power to discriminate changes in gas tension in magnitude predicted from conventional (i.e., arterial PCO2) control of ventilation. |
| Databáze: | OpenAIRE |
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