Anti-myelin antibodies in clinically isolated syndrome indicate the risk of multiple sclerosis in a Swiss cohort
| Autor: | T. Lauterburg, Heinrich Mattle, U. Walker, K. M. Rösler, J. Sellner, Isabell Greeve |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Nerve Tissue Proteins Antibodies Cohort Studies Central nervous system disease Myelin Adjuvants Immunologic Risk Factors Internal medicine medicine Humans Risk factor Clinically isolated syndrome biology business.industry Multiple sclerosis Myelin Basic Protein Interferon-beta General Medicine Middle Aged medicine.disease Oligodendrocyte Myelin-Associated Glycoprotein Treatment Outcome medicine.anatomical_structure Neurology Immunology Cohort biology.protein Female Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) Antibody business Interferon beta-1a Myelin Proteins Switzerland Transcription Factors |
| Zdroj: | Acta Neurologica Scandinavica. 116:207-210 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.2007.00872.x |
| Popis: | OBJECTIVES: In patients with a clinically isolated syndrome (CIS), the time interval to convert to clinically definite multiple sclerosis (CDMS) is highly variable. Individual and geographical prognostic factors remain to be determined. Whether anti-myelin antibodies may predict the risk of conversion to CDMS in Swiss CIS patients of the canton Berne was the subject of the study. METHODS: Anti-myelin oligodendrocyte glycoprotein and anti-myelin basic protein antibodies were determined prospectively in patients admitted to our department. RESULTS: After a mean follow-up of 12 months, none of nine antibody-negative, but 22 of 30 antibody-positive patients had progressed to CDMS. Beta-Interferon treatment delayed the time to conversion from a mean of 7.4 to 10.9 months. CONCLUSIONS: In a Swiss cohort, antibody-negative CIS patients have a favorable short-term prognosis, and antibody-positive patients benefit from early treatment. |
| Databáze: | OpenAIRE |
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