The maternal 14 bp Ins/Del polymorphism inHLA-Gis not associated with preeclampsia risk

Autor:	Leonardo Capistrano Ferreira, S. M. B. Jeronimo, Carlos E. M. Gomes, T. P. B. Lopes, T. B. Guimarães
Rok vydání:	2017
Předmět:	Adult 0301 basic medicine medicine.medical_specialty Offspring HELLP syndrome Immunology Preeclampsia Young Adult 03 medical and health sciences 0302 clinical medicine INDEL Mutation Pre-Eclampsia Pregnancy Risk Factors Genotype Genetics medicine Humans Genetic Predisposition to Disease Base Pairing Molecular Biology Alleles Genetic Association Studies reproductive and urinary physiology Genetics (clinical) Sequence Deletion Genetic association HLA-G Antigens Polymorphism Genetic 030219 obstetrics & reproductive medicine Eclampsia business.industry Obstetrics General Medicine Odds ratio medicine.disease female genital diseases and pregnancy complications Exact test Logistic Models Phenotype 030104 developmental biology embryonic structures Female business Maternal Age
Zdroj:	International Journal of Immunogenetics. 44:350-355
ISSN:	1744-3121
DOI:	10.1111/iji.12344
Popis:	The effect of HLA-G 14 bp Ins/Del polymorphism (rs371194629) on the risk of preeclampsia has been assessed in several populations, yet the results are still conflicting. Lack of power due to small sample sizes is a common cause of inconsistencies in genetic association studies. We aimed to test whether the maternal polymorphism is associated with preeclampsia, eclampsia or HELLP syndrome (acronym for Hemolysis, Elevation of Liver enzymes, Low Platelets). To achieve a statistical power greater than 0.90, a total of 741 women (332 controls, 246 preeclampsia, 57 eclampsia and 106 HELLP) were genotyped for the 14-bp Ins/Del polymorphism. The genetic association with disease status was assessed by Fisher's exact test and odds ratio (OR) estimates using logistic regression model adjusted for maternal age and parity status. Allele and genotype distributions were the same between control and case groups (p > .05). The polymorphism was not associated with the risk of developing preeclampsia [OR = 0.93 (0.72-1.19); p = .541], or eclampsia [OR = 0.90 (0.60-1.38); p = .628] nor HELLP syndrome [OR = 0.92 (0.66-1.28); p = .628]. This well-powered study clearly demonstrates that the maternal HLA-G 14-bp Ins/Del polymorphism is not associated with preeclampsia risk. However, as the offspring genotypes were not evaluated here, we could not rule out the effect of the foetal genotype on the preeclampsia pathogenesis.
Databáze:	OpenAIRE
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