Small (≤3cm) Hepatocellular Carcinoma in Cirrhosis: the Role of Double Contrast Agents MR Imaging vs. Multi-Detector Row CT
| Autor: | Franco Trevisani, F Fusco, Rita Golfieri, Alberto Bazzocchi, Silvio Cavuto, Fabio Piscaglia, Luigi Bolondi, E. Marini, Claudia Sama, Giuseppe Mazzella |
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| Přispěvatelé: | Golfieri R, Marini E, Bazzocchi A, Fusco F, Trevisani F, Sama C, Mazzella G, Cavuto S, Piscaglia F, Bolondi L |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Gadolinium DTPA Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular Contrast Media Liver · Neoplasms · Hepatocellular carcinoma · Cirrhosis · Contrast agents · SPIO-Enhanced MRI · Gd-DTPA-enhanced MRI · Multiphasic helical multidetector row CT (MDCT) Sensitivity and Specificity Predictive Value of Tests Medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Prospective Studies Magnetite Nanoparticles Neuroradiology Aged Aged 80 and over medicine.diagnostic_test business.industry Ultrasound Liver Neoplasms Magnetic resonance imaging Interventional radiology Dextrans General Medicine Middle Aged medicine.disease Mr imaging Magnetic Resonance Imaging Ferrosoferric Oxide Hepatocellular carcinoma Dynamic contrast-enhanced MRI cardiovascular system Female Radiology business Nuclear medicine Tomography X-Ray Computed Follow-Up Studies |
| Popis: | Purpose: We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (≤3 cm) hepatocellular carcinomas (HCCs). Materials and Methods: Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years’ follow-up (n=9). Results: One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions: DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions |
| Databáze: | OpenAIRE |
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